Description

(2R-Cis)-3-Acetoxy-5-[2-(Dimethylamino)Ethyl]-2,3-Dihydro-2-(4-Methoxyphenyl)-1,5-Benzothiazepin-4(5H)-One Monohydrochloride is a high-purity, complex organic compound with a defined stereochemistry. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents, particularly those targeting cardiovascular and neurological pathways. It is essential for research and development chemists, process scale-up teams, and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for diltiazem and related benzothiazepine-class calcium channel blockers.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the optimization and commercial-scale manufacturing of cardiovascular drugs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical production.
• Academic Research: Utilized in university and institutional labs for studying organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	(2R-Cis)-3-Acetoxy-5-[2-(Dimethylamino)Ethyl]-2,3-Dihydro-2-(4-Methoxyphenyl)-1,5-Benzothiazepin-4(5H)-One Monohydrochloride
CAS No.	42399-54-2
Molecular Formula	C24H29N2O4S • HCl
Molecular Weight	477.02 g/mol
Synonyms	Diltiazem Intermediate; Diltiazem Hydrochloride Impurity; (2S,3S)-Diltiazem Related Compound; cis-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester hydrochloride; 5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate hydrochloride; (2R,3S)-3-Acetyloxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
EINECS	Contact for details

Quality Control

Our (2R-Cis)-3-Acetoxy-5-[2-(Dimethylamino)Ethyl]-2,3-Dihydro-2-(4-Methoxyphenyl)-1,5-Benzothiazepin-4(5H)-One Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets exacting standards for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3S isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.