Description

Diltiazem CAS NO 42399-41-7 is a high-purity pharmaceutical active ingredient belonging to the benzothiazepine class of calcium channel blockers. It is a critical intermediate and active pharmaceutical ingredient (API) used in the manufacture of cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for hypertension, angina, and certain cardiac arrhythmias. Its reliable synthesis and stringent quality control are paramount for ensuring final drug product efficacy and safety.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for cardiovascular therapy.
• Hypertension Treatment: Formulation into tablets, capsules, and extended-release formulations for managing high blood pressure.
• Angina Pectoris Management: Used in medications to prevent and treat chest pain caused by reduced blood flow to the heart.
• Cardiac Arrhythmia Control: Key component in certain antiarrhythmic drugs, particularly for atrial fibrillation and flutter.
• Pharmaceutical Research: Serves as a reference standard and key intermediate in preclinical and clinical research for new cardiovascular drugs.
• Generic Drug Manufacturing: A vital raw material for producers of generic diltiazem hydrochloride medications.

Basic Information

Item	Detail
Product Name	Diltiazem
CAS No.	42399-41-7
Molecular Formula	C22H26N2O4S
Molecular Weight	414.52 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; Diltiazem Base; Diltiazem Free Base; (+)-cis-Diltiazem; CRD-401; Herbesser (Base Form); Altiazem; Cardizem (Base Form); Tildiem (Base Form); Anginyl
EINECS	255-799-7

Quality Control

Our Diltiazem is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available for every batch, confirming compliance with in-house specifications and relevant pharmacopeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.