Description

Nitrendipine is a potent dihydropyridine calcium channel blocker primarily used in pharmaceutical research and development. This compound is crucial for studying cardiovascular physiology and developing new therapeutic agents for hypertension and angina. It is a key intermediate and reference standard for pharmaceutical manufacturers, research institutions, and analytical laboratories engaged in cardiovascular drug discovery and quality control.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as the core active component in the formulation of antihypertensive and antianginal medications.
• Research & Development Reference Standard: Used as a high-purity analytical standard in method development, validation, and quality control testing within pharmaceutical labs.
• Biochemical Research: Employed in preclinical and clinical studies to investigate calcium channel mechanisms, vascular smooth muscle function, and cardiovascular disease pathways.
• Chemical Synthesis Intermediate: Acts as a critical building block for the synthesis of novel dihydropyridine derivatives and related pharmaceutical compounds.
• Analytical Testing: Utilized in HPLC, LC-MS, and other chromatographic systems for calibration and as a system suitability check.

Basic Information

Product Name	Nitrendipine
CAS No.	39562-70-4
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	Bayotensin; Bay e 5009; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester; Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester; Nitrendipinum; Nitrendipino
EINECS	254-488-7

Quality Control

Our Nitrendipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles upon request, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.