Description

R(+)-Verapamil Hydrochloride CAS NO 38176-10-2 is the pharmacologically active enantiomer of the calcium channel blocker verapamil, offering superior specificity for research and development applications. This high-purity chiral building block is critical for studying stereoselective drug action and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: As a key chiral intermediate and reference standard for investigating calcium channel pharmacology and developing enantiomerically pure cardiovascular drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the controlled production of the R-enantiomer of verapamil hydrochloride for advanced clinical formulations.
• Biochemical & Pharmacological Studies: A critical tool for in vitro and in vivo studies targeting L-type calcium channels, enabling research into hypertension, cardiac arrhythmias, and angina.
• Analytical Method Development: Serves as a high-purity standard for HPLC, LC-MS, and chiral separation method development and validation in quality control laboratories.
• Academic & Clinical Research: Supports fundamental research on ion channel function, drug-receptor interactions, and the stereochemistry of drug metabolism.

Basic Information

Product Name	R(+)-Verapamil Hydrochloride
CAS No.	38176-10-2
Molecular Formula	C27H39ClN2O4 • HCl
Molecular Weight	491.08 g/mol (for hydrochloride salt)
Synonyms	(+)-Verapamil Hydrochloride; (R)-Verapamil Hydrochloride; D-Verapamil Hydrochloride; (2R,3R)-Verapamil Hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride; (R)-(+)-Verapamil HCl; R-VER HCl; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzenecetonitrile Hydrochloride
EINECS	Contact for details

Quality Control

Our R(+)-Verapamil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, chiral purity, related substances, residual solvents, and other critical parameters. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.