Description

Methoxy-(-)-Verapamil Hydrochloride CAS NO 36622-40-9 is the specific enantiomer of the well-known calcium channel blocker, verapamil hydrochloride, distinguished by the methoxy substitution. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and metabolism. It is primarily required by pharmaceutical manufacturers, advanced research institutions, and fine chemical synthesis companies focused on cardiovascular therapeutics and chiral chemistry.

Application

• As a key chiral intermediate in the research and development of enantiomerically pure calcium channel blockers.
• For use in pharmacological studies investigating stereoselective effects on L-type calcium channels.
• In analytical method development as a reference standard for HPLC and chiral chromatography.
• For biochemical research exploring the mechanisms of vasodilation and cardiac arrhythmia treatment.
• In the synthesis of advanced pharmaceutical compounds where the specific (-)-enantiomer's activity is required.
• As a building block in medicinal chemistry for creating novel derivatives with targeted therapeutic profiles.

Basic Information

Item	Detail
Product Name	Methoxy-(-)-Verapamil Hydrochloride
CAS No.	36622-40-9
Molecular Formula	C27H39ClN2O4 • HCl
Molecular Weight	491.48 g/mol (for free base C27H39ClN2O4)
Synonyms	(-)-Verapamil Hydrochloride; (S)-Verapamil Hydrochloride; L-Verapamil Hydrochloride; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride; Methoxyverapamil HCl; Cordilox; Isoptin; Iproveratril Hydrochloride
EINECS	Contact for details

Quality Control

Our Methoxy-(-)-Verapamil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (-)-enantiomer
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.