Description

S(-)-Verapamil is the pharmacologically active enantiomer of the calcium channel blocker verapamil, offering superior specificity and potency for targeted research and development. This high-purity chiral building block is critical for advancing studies in cardiovascular pharmacology, multi-drug resistance (MDR) modulation, and neurological research. It is an essential raw material for pharmaceutical manufacturers, academic research institutions, and contract development organizations focused on enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• As a key chiral intermediate in the synthesis of enantiomerically pure cardiovascular drugs.
• For advanced pharmacological research into L-type calcium channel blockade and its effects.
• In studies investigating the reversal of P-glycoprotein mediated multi-drug resistance (MDR) in cancer cells.
• As a reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• For biochemical research exploring neurotransmitter release and neuronal calcium signaling.
• In the development of novel therapeutic agents for migraine prophylaxis and cluster headaches.

Basic Information

Item	Detail
Product Name	S(-)-Verapamil
CAS No.	36622-28-3
Molecular Formula	C27H38N2O4
Molecular Weight	454.60 g/mol
Synonyms	(-)-Verapamil; (S)-Verapamil; Levoverapamil; (2S)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(1-methylethyl)pentanenitrile; S-(-)-Verapamil; L-Verapamil; Verapamil S-(-)-isomer
EINECS	Contact for details

Quality Control

Our S(-)-Verapamil is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to confirm identity and meet stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.