Description

Diethyl 4-(4-Chlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate is a high-purity, synthetically derived 1,4-dihydropyridine (DHP) derivative, a key structural motif in medicinal chemistry. This compound matters as a versatile and critical pharmaceutical intermediate for the research and development of calcium channel modulators. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a core building block for the synthesis of 1,4-dihydropyridine-class calcium channel blockers, which are used to treat cardiovascular conditions like hypertension and angina.
• Research Chemical: Used in academic and industrial research to study structure-activity relationships (SAR) and develop new drug candidates with modified pharmacological profiles.
• Reference Standard: Employed as an analytical standard in quality control (QC) and quality assurance (QA) laboratories for method development and impurity profiling in pharmaceutical manufacturing.
• Chemical Synthesis: Acts as a precursor for further chemical modifications, enabling the creation of libraries of compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Diethyl 4-(4-Chlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate
CAS No.	35929-79-4
Molecular Formula	C19H22ClNO4
Molecular Weight	363.84 g/mol
Synonyms	4-(4-Chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester; Diethyl 1,4-dihydro-2,6-dimethyl-4-(4-chlorophenyl)-3,5-pyridinedicarboxylate; Felodipine Intermediate; Hantzsch Ester Derivative; 1,4-DHP Derivative; 4-(p-Chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid Diethyl Ester; NSC 339539
EINECS	Contact for details

Quality Control

Our Diethyl 4-(4-Chlorophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.