Description

Flunarizine Dihydrochloride is a high-purity pharmaceutical active ingredient, a selective calcium channel blocker with vasodilatory properties. This compound is critical for the research and development of therapeutic agents targeting cerebral and peripheral circulatory disorders. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development of treatments for conditions such as migraine prophylaxis and vertigo.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of finished dosage forms, particularly for neurological and vascular applications.
• Migraine Prophylaxis: Key component in the development of preventative medications for chronic and severe migraine headaches.
• Vertigo & Balance Disorder Treatment: Used in research and production of drugs aimed at managing symptoms of vertigo and related vestibular disorders.
• Vasodilatory Research: Serves as a reference standard and active compound in cardiovascular and cerebrovascular research studies.
• Neurological Disorder Research: Employed in preclinical and clinical research for investigating calcium channel mechanisms in various neurological conditions.
• Reference Standard: Used in analytical laboratories for quality control, method development, and regulatory compliance testing of pharmaceutical products.

Basic Information

Product Name	Flunarizine Dihydrochloride
CAS No.	30484-77-6
Molecular Formula	C26H26F2N2 • 2HCl
Molecular Weight	477.42 g/mol
Synonyms	Flunarizine HCl; (E)-1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine Dihydrochloride; R 14950; Sibelium; Flunarizinium Dichloride; 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Our Flunarizine Dihydrochloride is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing including identification, assay, and impurity profiling to ensure compliance with in-house specifications and support regulatory filings. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.