Description

Fimasartan CAS NO 247257-48-3 is a potent and selective angiotensin II receptor blocker (ARB) used as an active pharmaceutical ingredient (API). This compound is critical for the development and manufacturing of antihypertensive medications, offering targeted action on the renin-angiotensin system. It is primarily required by pharmaceutical companies and research institutions engaged in cardiovascular drug formulation and advanced therapeutic research.

Application

• Primary Pharmaceutical Ingredient: Core API for the manufacture of prescription antihypertensive tablets and combination therapies.
• Cardiovascular Research: A key reference standard in pharmacological studies investigating angiotensin receptor mechanisms and blood pressure regulation.
• Generic Drug Development: Serves as the active component for companies developing bioequivalent versions of branded fimasartan medications.
• Formulation R&D: Used in pre-formulation studies, stability testing, and the development of novel drug delivery systems.
• Analytical Standard: High-purity grade material for use as a calibration standard in HPLC, LC-MS, and other quality control assays.
• Clinical Trial Material (CTM): Supplied under GMP conditions for use in Phase I-III clinical studies.

Basic Information

Product Name	Fimasartan
CAS No.	247257-48-3
Molecular Formula	C27H27N5O3S
Molecular Weight	501.60 g/mol
Synonyms	BR-A-657; Fimasartan Potassium; Kanarb; (2-Butyl-5-dimethylaminothiocarbonyl-4-methylthio-1H-imidazol-1-yl)methyl-1-([2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl)-2-ethylbenzimidazole-7-carboxylate; BR-A-657K; 1H-Imidazole-7-carboxylic acid, 2-butyl-5-(dimethylamino)thiocarbonyl-4-(methylthio)-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Fimasartan is manufactured and tested to meet stringent pharmacopeial standards, including ICH Q7 guidelines for active pharmaceutical ingredients. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure traceability and compliance with global regulatory requirements, including FDA and EMA submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to protect from humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.