Description

n-Type Calcium Channel Blocker-1 is a potent and selective pharmacological agent designed to inhibit n-type voltage-gated calcium channels. This compound is a critical research tool for investigating neuronal signaling pathways, pain mechanisms, and cardiovascular physiology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on neuroscience and drug discovery.

Application

• Neuroscience Research: Used as a selective probe to study the role of N-type calcium channels in synaptic transmission, neurotransmitter release, and neuronal excitability.
• Pain Research & Analgesic Development: Investigated for its potential in modulating nociceptive signaling pathways, serving as a reference compound in the development of novel non-opioid pain therapeutics.
• Cardiovascular Research: Employed in studies exploring the regulation of vascular tone and cardiac function through neuronal calcium channel modulation.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in assay development and screening campaigns for identifying new calcium channel modulators.
• Mechanistic & Target Validation Studies: Essential for validating the biological role of the Cav2.2 (α1B) subunit in disease models and confirming target engagement for novel drug candidates.

Basic Information

Product Name	n-Type Calcium Channel Blocker-1
CAS No.	241499-17-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-Type Calcium Channel Blocker 1; Calcium Channel Blocker, N-Type-1; Blocker-1, n-Type Calcium Channel; CAS 241499-17-2; N-Type CCB-1; Cav2.2 Channel Blocker-1; ω-Conotoxin GVIA synthetic analog (research context); Neuronal Calcium Channel Inhibitor-1
EINECS	Contact for details

Quality Control

Our n-Type Calcium Channel Blocker-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.