Description

Benazepril Hydrochloride is a high-purity active pharmaceutical ingredient (API) primarily used as an angiotensin-converting enzyme (ACE) inhibitor. This compound is critical for the formulation of antihypertensive and heart failure medications, offering reliable therapeutic efficacy. It is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug production and advanced pharmacological research.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for treating hypertension (high blood pressure).
• Cardiovascular Therapeutics: Key component in formulations for managing heart failure and improving survival post-myocardial infarction.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of branded ACE inhibitor drugs.
• Clinical Research: Used in preclinical and clinical studies for developing new cardiovascular treatment protocols.
• Pharmaceutical R&D: Serves as a reference standard and building block in medicinal chemistry for novel drug discovery.
• Dosage Form Development: Utilized in the development of various dosage forms, including tablets and capsules.

Basic Information

Product Name	Benazepril Hydrochloride
CAS No.	215447-90-8
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol
Synonyms	Benazepril HCl; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; CGS-14824A; CGS 14824; Lotensin (brand name active ingredient); Benzazepril Hydrochloride
EINECS	Contact for details

Quality Control

Our Benazepril Hydrochloride is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including assay, impurity profiling, and residual solvent analysis to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) documenting purity, identity, and safety parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.