Description

1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-[2-[(3,3-Diphenylpropyl)Methylamino]-1,1-Dimethylethyl] 5-Ethyl Ester Hydrochloride is a high-purity, complex organic salt of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for investigating novel therapeutic pathways, particularly in cardiovascular and neurological domains. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need this material for process development, analytical method validation, and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel drug candidates, particularly calcium channel blockers or related therapeutic agents.
• Active Pharmaceutical Ingredient (API) Research: Used as a reference standard or as the active component in formulation studies for new drug development projects.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate biological activity, receptor binding, and pharmacological mechanisms.
• Process Chemistry & Scale-Up: Essential for optimizing synthetic routes, developing purification protocols, and establishing manufacturing processes in pilot plants.
• Analytical Standard: Provides a high-purity benchmark for developing and validating analytical methods such as HPLC, LC-MS, and NMR for quality control.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and cGMP production for clinical trial materials.

Basic Information

Product Name	1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-[2-[(3,3-Diphenylpropyl)Methylamino]-1,1-Dimethylethyl] 5-Ethyl Ester Hydrochloride
CAS No.	210579-71-8
Molecular Formula	C40H47N3O6 • HCl
Molecular Weight	694.28 g/mol (Free base: 657.82 g/mol)
Synonyms	Miberfadil Dihydrochloride (common research name); Mibefradil Dihydrochloride (alternative spelling); Mibefradil HCl; Ro 40-5967; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] ester 5-ethyl ester hydrochloride; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-ethyl ester, hydrochloride; Posicor (associated brand name for related compound).
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-[2-[(3,3-Diphenylpropyl)Methylamino]-1,1-Dimethylethyl] 5-Ethyl Ester Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing comprehensive specifications including assay, impurity profile, and residual solvents are available upon request. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.