Description

Icrf-186 is a synthetic chemical compound belonging to the bisdioxopiperazine class, known for its role as a topoisomerase II inhibitor. This compound is of significant interest in biochemical and pharmacological research for its potential to modulate DNA topology and cellular processes. It serves as a critical research-grade material for scientists in pharmaceutical development, oncology research, and molecular biology, particularly in studies related to enzyme function and anticancer agent mechanisms.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the investigation of novel chemotherapeutic agents.
• Biochemical Studies: Employed as a potent topoisomerase II inhibitor to study DNA replication, transcription, and repair mechanisms in vitro.
• Oncology Research: Investigated for its cytotoxic properties and potential application in cancer cell line studies and preclinical models.
• Academic Research: Utilized in university and institutional labs for fundamental research on cell cycle regulation and apoptosis.
• Chemical Synthesis: Serves as a key intermediate or building block for the synthesis of more complex bisdioxopiperazine derivatives.
• Reference Material: Provides a high-purity standard for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Icrf-186
CAS No.	24613-06-7
Molecular Formula	C20H24N4O4
Molecular Weight	384.43 g/mol
Synonyms	ICRF-186; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Dexrazoxane impurity; Bisdioxopiperazine; ICRF 186; NSC-169780; Razoxane impurity; (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
EINECS	Contact for details

Quality Control

Our Icrf-186 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.