Description

1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Bis(1-Methylethyl) Ester is a high-purity pharmaceutical intermediate of significant commercial and research interest. Its core value lies in its role as a key precursor in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly calcium channel blockers. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, fine chemical, and life science sectors seeking reliable, high-quality building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of dihydropyridine-class calcium channel blocker APIs.
• Research & Development: Serves as a key starting material (KSM) or building block in medicinal chemistry for developing new cardiovascular therapeutics.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to create complex molecules with specific pharmacological activity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial production of related drug substances.

Basic Information

Product Name	1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Bis(1-Methylethyl) Ester
CAS No.	21881-78-7
Molecular Formula	C22H26N2O6
Molecular Weight	414.46 g/mol
Synonyms	Isopropyl 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, Bis(1-methylethyl) Ester; Felodipine Impurity; Felodipine Related Compound A; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid Diisopropyl Ester; Diisopropyl 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; DHP Derivative
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid Bis(1-Methylethyl) Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.