Description

m-Nifedipine CAS NO 21881-77-6 is a key chemical intermediate and a positional isomer of the well-known calcium channel blocker, nifedipine. This compound is of significant value in pharmaceutical research and development, particularly for structure-activity relationship (SAR) studies and the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in cardiovascular drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the research and synthesis of dihydropyridine-based calcium channel blockers and related analogs.
• Chemical Reference Standard: Used as a high-purity standard in analytical laboratories for method development, validation, and quality control testing of pharmaceutical products.
• Research & Development: Essential for academic and industrial R&D focused on medicinal chemistry, pharmacology, and exploring new therapeutic applications for dihydropyridine derivatives.
• Process Chemistry: Employed in route scouting and optimization studies for the scalable production of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	m-Nifedipine
CAS No.	21881-77-6
Molecular Formula	C17H18N2O6
Molecular Weight	346.34 g/mol
Synonyms	3-Nitrophenyl Nifedipine; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester; 3'-Nitronifedipine; m-Nitronifedipine; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Acid Dimethyl Ester; BAY a 7168; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our m-Nifedipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.