Description

Nifedipine CAS NO 21829-75-4 is a dihydropyridine-class calcium channel blocker widely recognized for its potent vasodilatory effects. This active pharmaceutical ingredient (API) is critical for the formulation of medications used to manage cardiovascular conditions. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for hypertension and angina pectoris.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and antianginal medications, including extended-release formulations.
• Cardiovascular Research: A key reference standard and tool compound in pharmacological studies of calcium channels and vascular smooth muscle.
• Generic Drug Manufacturing: Sourcing for the production of cost-effective generic versions of nifedipine-based drugs for global markets.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for quality control and assay development in analytical laboratories.
• Formulation Development: Serves as the core component in R&D for novel drug delivery systems, such as transdermal patches or gastro-retentive systems.

Basic Information

Product Name	Nifedipine
CAS No.	21829-75-4
Molecular Formula	C₁₇H₁₈N₂O₆
Molecular Weight	346.34 g/mol
Synonyms	3,5-Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; BAY a 1040; Adalat; Nifedical; Procardia; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
EINECS	244-598-3

Quality Control

Our Nifedipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and can be tailored to meet specific pharmacopeial requirements such as USP or EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its strictly light-sensitive nature, handling and packaging must be performed under conditions that protect the material from all light exposure to prevent degradation.

Specification

Item	Specification
Appearance	Yellow crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.