Description

Etripamil is a novel, investigational calcium channel blocker specifically designed for rapid, patient-administered treatment. This compound is of significant interest for its potential to provide on-demand therapeutic intervention in acute cardiovascular settings. It is primarily targeted at the pharmaceutical research and development sector for the formulation of new drug products.

Application

• Pharmaceutical R&D: Key intermediate or active pharmaceutical ingredient (API) in the development of novel cardiovascular therapeutics.
• Clinical Trial Material: Sourcing of high-purity material for Phase I-III clinical studies investigating new treatment paradigms.
• Mechanistic Studies: Used in preclinical research to study the pharmacology of L-type calcium channel blockade in specific tissues.
• Formulation Development: Serves as a reference standard or raw material for developing nasal spray or other rapid-delivery dosage forms.
• Bioanalytical Method Development: Used as a standard for developing and validating HPLC, LC-MS, or other analytical methods for pharmacokinetic studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	Etripamil
CAS No.	1593673-23-4
Molecular Formula	C27H30N2O5S
Molecular Weight	494.60 g/mol
Synonyms	MSP-2017; (R)-2-(3,4-Dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile; (R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile; Gated Calcium Channel Blocker MSP-2017; Etripamil Hydrochloride (salt form precursor)
EINECS	Contact for details

Quality Control

Our Etripamil is manufactured and controlled under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.