Description

Azilsartan Ethanaminium Salt 2:1 is a high-purity pharmaceutical intermediate, specifically the ethanaminium salt form of the angiotensin II receptor blocker (ARB) Azilsartan. This compound is critical for ensuring the consistent quality, bioavailability, and stability of finished drug products. It is primarily required by manufacturers in the pharmaceutical industry engaged in the development and production of antihypertensive medications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the commercial manufacturing of Azilsartan medoxomil, a leading antihypertensive drug.
• Hypertension Drug Formulation: Used in the development and scale-up of final dosage forms, such as tablets and capsules, for treating high blood pressure.
• Pharmaceutical Research & Development: Serves as a critical reference standard and building block in preclinical and clinical studies for new cardiovascular therapies.
• Process Chemistry Optimization: Employed to improve synthetic routes, yield, and purity profiles in GMP-compliant production processes.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent generic versions of branded Azilsartan medications.
• Analytical Method Development: Used as a high-purity standard for HPLC, LC-MS, and other analytical techniques to ensure product quality control.

Basic Information

Product Name	Azilsartan Ethanaminium Salt 2:1
CAS No.	1309776-70-2
Molecular Formula	C30H28N4O5 • 2(C2H8N)
Molecular Weight	Contact for details
Synonyms	Azilsartan diethylamine salt; Azilsartan EA salt; 2-ethoxy-1-({4-[2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]phenyl}methyl)-1H-benzimidazole-7-carboxylic acid compound with N-ethylethanamine (2:1); TAK-536 Ethanaminium Salt; CS-866 Ethanaminium Salt
EINECS	Contact for details

Quality Control

Our Azilsartan Ethanaminium Salt 2:1 is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability, consistency, and compliance with relevant guidelines for API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.