Description

Zofenoprilat n-Ethyl Succinimide is a key advanced pharmaceutical intermediate, specifically the active metabolite of the prodrug Zofenopril. This compound is critical for research and development in cardiovascular pharmacology, offering a direct pathway for studying angiotensin-converting enzyme (ACE) inhibition mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on developing and analyzing next-generation antihypertensive and cardioprotective agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis and research of Zofenopril and related prodrug molecules.
• Biochemical Research: Used as a reference standard and active compound in in vitro and in vivo studies to investigate ACE inhibition kinetics and pharmacodynamics.
• Metabolite Studies: Essential for analytical method development and validation in pharmacokinetic studies to quantify the active metabolite levels.
• Process Chemistry: Employed in route scouting and optimization for the efficient production of cardiovascular active pharmaceutical ingredients (APIs).
• Quality Control Reference: Acts as a high-purity certified reference material (CRM) for HPLC, LC-MS, and NMR analysis in quality assurance laboratories.

Basic Information

Item	Details
Product Name	Zofenoprilat n-Ethyl Succinimide
CAS No.	1217526-22-1
Molecular Formula	C22H28N2O5S
Molecular Weight	432.54 g/mol
Synonyms	(4S)-1-[(2S)-3-(Benzoylthio)-2-methylpropanoyl]-4-(phenylthio)-L-proline n-Ethyl Succinimide Ester; Zofenoprilat Ethyl Succinimide; Zofenopril Active Metabolite Succinimide Ester; SQ 32961; (S,S)-Zofenoprilat N-Ethyl Succinimide
EINECS	Contact for details

Quality Control

Our Zofenoprilat n-Ethyl Succinimide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identity confirmation by spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.