Description

Triphyl Valsartan is a high-purity pharmaceutical intermediate, specifically a triphilic prodrug form of the widely used antihypertensive agent Valsartan. This compound is critical for enhancing the bioavailability and targeted delivery of the active pharmaceutical ingredient (API) in advanced drug formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation cardiovascular medications, controlled-release systems, and combination therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of prodrug formulations of Valsartan.
• Advanced Drug Delivery Systems: Used in the development of liposomal, nanoparticle, or other novel delivery platforms to improve solubility and absorption.
• Cardiovascular Drug R&D: Serves as a critical material in research for new hypertension and heart failure treatments with modified release profiles.
• Controlled-Release Formulations: Integral to creating extended-release or targeted-release dosage forms to enhance patient compliance and therapeutic efficacy.
• Combinatorial Chemistry: Used in libraries for screening and developing new chemical entities with improved pharmacokinetic properties.
• Reference Standard: Can be utilized as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	Triphyl Valsartan
CAS No.	195435-23-5
Molecular Formula	C29H41N5O6
Molecular Weight	555.67 g/mol
Synonyms	Valsartan Triphilic Prodrug; Valsartan Triphyl Ester; (S)-3-Methyl-2-(pentanoyl-{2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl}methyl)amino)butanoic acid triphyl ester; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, triphyl ester; N-Valeryl-N-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-L-valine triphyl ester
EINECS	Contact for details

Quality Control

Our Triphyl Valsartan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by IR and NMR spectroscopy, to ensure it meets exacting standards for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.