Description

(R)-(-)-Niguldipine Hydrochloride CAS NO 189624-85-9 is a high-purity, enantiomerically pure calcium channel blocker of the dihydropyridine class. This compound is a critical chiral intermediate and reference standard for pharmaceutical research and development, particularly in cardiovascular and neurological studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require a reliable source of a specific stereoisomer for drug discovery, process development, and analytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Drug Discovery & Development: Serves as a key chiral building block and pharmacological tool in the research of calcium channel modulators for treating hypertension and angina.
• Biochemical Research: Employed in in vitro and ex vivo studies to investigate L-type calcium channel function and signal transduction pathways.
• Process Chemistry: Acts as a critical intermediate in the asymmetric synthesis of advanced pharmaceutical compounds.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and as a teaching compound for stereochemistry.
• Metabolite Synthesis: Used in the preparation of labeled or unlabeled metabolites for pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.

Basic Information

Product Name	(R)-(-)-Niguldipine Hydrochloride
CAS No.	189624-85-9
Molecular Formula	C28H31N3O6 · HCl
Molecular Weight	542.02 g/mol
Synonyms	(R)-Niguldipine HCl; (R)-(-)-Niguldipine Hydrochloride; (R)-B859-35; (R)-(–)-5-[(Dibutylamino)ethyl] 3-ethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride; (R)-BAY-K-8644 analog; (R)-Enantiomer of Niguldipine Hydrochloride; (R)-Calcium Channel Agonist BAY-K-8644 Derivative
EINECS	Contact for details

Quality Control

Our (R)-(-)-Niguldipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.