Description

(R)-Lercanidipine Hydrochloride CAS NO 187731-34-6 is the single enantiomer of the dihydropyridine calcium channel blocker, lercanidipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories, process chemists, and manufacturers focused on producing advanced antihypertensive drugs with specific stereochemical profiles.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of enantiopure lercanidipine hydrochloride.
• Cardiovascular Drug Research: Used in preclinical and clinical studies to investigate the specific pharmacological activity of the (R)-enantiomer.
• Process Development & Optimization: Serves as a reference standard and starting material for developing and scaling up asymmetric synthesis routes.
• Analytical Method Development: Employed as a high-purity standard for HPLC, chiral chromatography, and spectroscopic methods to ensure product quality and enantiomeric excess.
• Regulatory Submissions: Used to prepare batches for stability studies, impurity profiling, and other documentation required for drug master files (DMFs) and regulatory approvals.

Basic Information

Product Name	(R)-Lercanidipine Hydrochloride
CAS No.	187731-34-6
Molecular Formula	C36H42ClN3O6 • HCl
Molecular Weight	684.66 g/mol (for hydrochloride salt)
Synonyms	(R)-Lercanidipine HCl; (R)-2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride; (R)-Enantiomer of Lercanidipine Hydrochloride; (R)-Lercanidipine; (R)-Zanidip; (R)-Lercanidipine Hydrochloride; (R)-3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester, hydrochloride, (R)-
EINECS	Contact for details

Quality Control

Our (R)-Lercanidipine Hydrochloride is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) detailing all specifications and results, ensuring compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.