Description

2-Butyl-3,4-Dihydro-N,n-Dimethyl-4-Oxo-3-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl-4-Yl]Methyl]]-5H-Imidazo[4,5-C]Pyridine-5-Acetamide Hydrochloride is a high-purity, non-peptide angiotensin II receptor antagonist intermediate. This compound is critical for ensuring the efficacy and safety of final active pharmaceutical ingredients (APIs) in cardiovascular therapeutics. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development and production of antihypertensive and heart failure medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced angiotensin II receptor blockers (ARBs).
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating novel cardiovascular drugs targeting hypertension and heart failure.
• Process Chemistry & Scale-Up: Essential for process optimization and pilot-scale manufacturing of final drug substances.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Academic & Institutional Research: Used in pharmacological studies investigating renin-angiotensin system pathways.

Basic Information

Product Name	2-Butyl-3,4-Dihydro-N,n-Dimethyl-4-Oxo-3-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl-4-Yl]Methyl]]-5H-Imidazo[4,5-C]Pyridine-5-Acetamide Hydrochloride
CAS No.	187683-79-0
Molecular Formula	C31H33N9O2 · HCl
Molecular Weight	600.12 g/mol
Synonyms	Valsartan Impurity; Valsartan Related Compound; 2-Butyl-3-({[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl})-3,4-dihydro-N,N-dimethyl-4-oxo-5H-imidazo[4,5-c]pyridine-5-acetamide hydrochloride; Valsartan Intermediate Hydrochloride; 5H-Imidazo[4,5-c]pyridine-5-acetamide, 2-butyl-3,4-dihydro-N,N-dimethyl-4-oxo-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, hydrochloride; L-158,809 Intermediate; ZD-7155 Intermediate; Telmisartan Related Compound H
EINECS	Contact for details

Quality Control

Our 2-Butyl-3,4-Dihydro-N,n-Dimethyl-4-Oxo-3-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl-4-Yl]Methyl]]-5H-Imidazo[4,5-C]Pyridine-5-Acetamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality standards are designed to meet the requirements of cGMP, ICH Q7, and major pharmacopoeial guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.