Description

(S)-Lercanidipine Hydrochloride CAS NO 184866-29-3 is the single enantiomer, S-isomer of the dihydropyridine calcium channel blocker lercanidipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories, process chemists, and manufacturers focused on producing advanced active pharmaceutical ingredients (APIs) with specific stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure (S)-Lercanidipine API.
• Cardiovascular Drug Research: Used in preclinical and clinical studies to investigate the pharmacokinetics and efficacy of the specific S-enantiomer.
• Process Development & Scale-up: Serves as a reference standard and starting material for optimizing asymmetric synthesis routes in pilot and commercial manufacturing.
• Analytical Standard: Employed as a high-purity standard for HPLC, LC-MS, and chiral analysis methods to ensure product quality and regulatory compliance.
• Metabolite Studies: Utilized in the synthesis and identification of specific drug metabolites for safety and toxicology profiling.

Basic Information

Product Name	(S)-Lercanidipine Hydrochloride
CAS No.	184866-29-3
Molecular Formula	C36H41N3O6 • HCl
Molecular Weight	648.19 g/mol
Synonyms	(S)-Lercanidipine HCl; (S)-2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride; (S)-Lercanidipine monohydrochloride; (S)-Lercanidipine hydrochloride; Lercanidipine (S)-enantiomer hydrochloride; (S)-3-[1-[(3,3-Diphenylpropyl)methylamino]-2-methylpropan-2-yl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride; Zanedip (S-isomer) hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Lercanidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical R&D and process applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.