Description

2-Propyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]-1,5,7,9-Tetr Azabicyclo[4.3.0]Nona-2,4,6,8-Tetraene is a complex heterocyclic organic compound featuring a fused tetrazole and tetraazabicyclic structure, serving as a highly valuable advanced pharmaceutical intermediate. Its unique molecular architecture makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular interactions. This compound is essential for research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for cardiovascular and central nervous system (CNS) targeted therapies.
• Angiotensin II Receptor Antagonist Research: Core scaffold for developing sartan-class compounds due to the bioactive tetrazole moiety.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Biochemical Research: Serves as a ligand or probe in biochemical assays studying receptor-ligand interactions.
• High-Purity Reference Standard: Utilized as an analytical standard for quality control and method development in API manufacturing.
• Contract Research Organization (CRO) & CDMO Projects: Supplied for custom synthesis and scale-up development under cGMP guidelines.

Basic Information

Product Name	2-Propyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]-1,5,7,9-Tetr Azabicyclo[4.3.0]Nona-2,4,6,8-Tetraene
CAS No.	168152-92-9
Molecular Formula	C22H21N9
Molecular Weight	411.47 g/mol
Synonyms	2-Propyl-3-((4'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-2-yl)methyl)-1,5,7,9-tetraazabicyclo[4.3.0]nona-2,4,6,8-tetraene; Biphenyl-tetrazole tetraazabicyclononatetraene derivative; Losartan related intermediate B; Tetrazole-biphenyl fused tetraaza compound; 1,5,7,9-Tetraazabicyclo[4.3.0]nona-2,4,6,8-tetraene, 2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-; CAS 168152-92-9
EINECS	Contact for details

Quality Control

Our 2-Propyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]-1,5,7,9-Tetr Azabicyclo[4.3.0]Nona-2,4,6,8-Tetraene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports development under cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.