Description

Clevidipine is a highly selective, ultra-short-acting dihydropyridine calcium channel blocker. Its primary value lies in providing rapid and precise control of blood pressure in critical care settings, with a fast onset and offset of action that allows for easy titration. This product is essential for pharmaceutical manufacturers and research institutions developing injectable formulations for the management of acute hypertension, particularly during and after surgical procedures. We supply high-purity Clevidipine CAS NO 166432-28-6 to support the global pharmaceutical supply chain.

Application

• Active Pharmaceutical Ingredient (API) for injectable antihypertensive medications.
• Critical Care Formulations used in hospital settings for the rapid reduction of severe hypertension.
• Perioperative Blood Pressure Management during cardiac surgery and other major surgical procedures.
• Research & Development of novel cardiovascular therapeutics and drug delivery systems.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Pharmacological Studies investigating calcium channel modulation and vascular tone.

Basic Information

Item	Detail
Product Name	Clevidipine
CAS No.	166432-28-6
Molecular Formula	C21H23Cl2NO6
Molecular Weight	456.32 g/mol
Synonyms	Clevidipine Butyrate; (RS)-Clevidipine; H 324/38; Cleviprex (Trade Name); Butyric acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester; Isopropyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our Clevidipine is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results against relevant specifications is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.