Description

5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride is a high-purity, non-peptidic small molecule compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) for investigating novel therapeutic pathways, particularly in cardiovascular and metabolic disease research. It is essential for R&D chemists, process development scientists, and manufacturers engaged in the synthesis of next-generation pharmaceutical agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates targeting specific receptor pathways.
• Research & Development: Used as a reference standard and bioactive compound in preclinical studies for cardiovascular and metabolic disorders.
• Process Chemistry: Serves as a critical starting material or intermediate in scale-up and optimization of API manufacturing processes.
• Analytical Standard: Provides a high-purity benchmark for method development and validation in quality control laboratories.
• Biochemical Research: Utilized in vitro and in vivo studies to explore mechanisms of action and pharmacological profiles.

Basic Information

Item	Detail
Product Name	5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride
CAS No.	157066-77-8
Molecular Formula	C36H38N4O5 • HCl
Molecular Weight	643.18 g/mol (Free base: 606.72 g/mol)
Synonyms	Methyl 5-({[3-(4,4-diphenylpiperidin-1-yl)propyl]carbamoyl})-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-3-carboxylate hydrochloride; Lercanidipine Impurity; Lercanidipine Related Compound; 4-(4-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-[3-(4,4-diphenyl-1-piperidinyl)propyl]amide hydrochloride; Lercanidipine Hydrochloride Impurity; CAS 157066-77-8
EINECS	Contact for details

Quality Control

Our 5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.