Description

5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride is a high-purity, non-peptidic chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its specific structural framework, which is crucial for modulating biological activity in therapeutic candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel active pharmaceutical ingredients (APIs), particularly in cardiovascular and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Employed as an analytical standard in method development and quality control for API manufacturing.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological screening and biological evaluation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride
CAS No.	157066-76-7
Molecular Formula	C36H38N4O5 • HCl
Molecular Weight	643.18 g/mol
Synonyms	Methyl 5-({[3-(4,4-diphenylpiperidin-1-yl)propyl]carbamoyl})-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-3-carboxylate hydrochloride; Lercanidipine Impurity; Lercanidipine Related Compound; 1,4-Dihydro-2,6-dimethyl-4-(4-nitrophenyl)-5-({[3-(4,4-diphenyl-1-piperidinyl)propyl]amino}carbonyl)-3-pyridinecarboxylic acid methyl ester hydrochloride; Lercanidipine Hydrochloride Intermediate; CAS 157066-76-7
EINECS	Contact for details

Quality Control

Our 5-[[[3-(4,4-Diphenyl-1-Piperidinyl)Propyl]Amino]Carbonyl]-1,4-Dihydro-2,6-Dimethyl-4-(4-Nitrophenyl)-3-Pyridinecarboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.