Description

Pratosartan CAS NO 153804-05-8 is a potent and selective angiotensin II receptor antagonist (ARB) belonging to the sartan class of pharmaceuticals. This compound is a key active pharmaceutical ingredient (API) used in the development of antihypertensive medications to treat high blood pressure and related cardiovascular conditions. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis of novel therapeutics for cardiovascular disease management.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the core therapeutic agent in the formulation of antihypertensive drugs.
• Hypertension Treatment: Development of medications for the management of essential hypertension.
• Cardiovascular Research: A critical reference standard and intermediate in preclinical and clinical research for heart failure, diabetic nephropathy, and other angiotensin II-mediated disorders.
• Pharmaceutical Intermediates: Serves as a high-purity intermediate for the synthesis of more complex drug molecules or prodrugs within the sartan family.
• Analytical Standard: Used as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Formulation Development: Employed in R&D for creating various dosage forms such as tablets and capsules.

Basic Information

Product Name	Pratosartan
CAS No.	153804-05-8
Molecular Formula	C₂₃H₂₆N₄O₃
Molecular Weight	406.48 g/mol
Synonyms	Pratosartan; 2-Butyl-5-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-4-chloro-1H-imidazole-5-methanol; KT3-671; Pratosartan (USAN); UNII-9H8L6L3T4H; 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-methanol
EINECS	Contact for details

Quality Control

Our Pratosartan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical R&D and API synthesis. Specifications typically align with pharmacopeial guidelines for related ARB compounds. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.