Description

S-Triazolo(1,5-A)Pyrimidin-7-Ol, 2-Methyl-5-Propyl-6-((2'-(1H-Tetrazol-5-Yl) (1,1'-Biphenyl)-4-Yl)Methyl)-, Sulfate is a high-purity, non-peptide angiotensin II receptor antagonist intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting cardiovascular conditions. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of sartan-class antihypertensive drugs.

Application

• Key Intermediate for Sartan APIs: Primary use in the synthesis of advanced angiotensin II receptor blockers (ARBs) such as Valsartan, Losartan, and related analogs.
• Pharmaceutical Research & Development: Serves as a crucial scaffold for medicinal chemists exploring new cardiovascular drug candidates and conducting structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, cost-effective manufacturing routes for bulk API production.
• Reference Standard: Employed as an analytical reference standard for quality control and regulatory filing (e.g., DMF, CMC sections) in pharmaceutical manufacturing.
• Fine Chemical Synthesis: Utilized in the custom synthesis of complex, biphenyl-tetrazole containing molecules for various therapeutic areas.

Basic Information

Item	Details
Product Name	S-Triazolo(1,5-A)Pyrimidin-7-Ol, 2-Methyl-5-Propyl-6-((2'-(1H-Tetrazol-5-Yl) (1,1'-Biphenyl)-4-Yl)Methyl)-, Sulfate
CAS No.	151733-55-0
Molecular Formula	C30H28N10O5S
Molecular Weight	640.67 g/mol
Synonyms	Valsartan Intermediate; 2-Methyl-5-propyl-6-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol sulfate; L-Valine, N-(1-oxopentyl)-, (2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl ester sulfate salt intermediate; Biphenyltetrazole Triazolopyrimidine Sulfate; 151733-55-0; Valsartan Key Intermediate; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine intermediate sulfate
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality systems are designed to support regulatory requirements for Drug Master File (DMF) submissions and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.