Description

Milfasartan is a high-purity pharmaceutical intermediate and research chemical, identified by CAS NO 148564-47-0. It serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the cardiovascular therapeutic area. This compound is essential for pharmaceutical manufacturers and R&D institutions focused on developing and producing novel angiotensin II receptor antagonists.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of sartan-class Active Pharmaceutical Ingredients (APIs) for hypertension and heart failure treatments.
• Research & Development: Key starting material (KSM) or advanced intermediate in medicinal chemistry programs targeting the renin-angiotensin system.
• Process Development: Used in scaling up and optimizing manufacturing routes for final drug substances in GMP environments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Milfasartan
CAS No.	148564-47-0
Molecular Formula	C25H20N6O3
Molecular Weight	452.46 g/mol
Synonyms	Milfasartan; 2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-ene-4-one; BMS-180560; 148564-47-0; 2-butyl-5-chloro-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
EINECS	Contact for details

Quality Control

Our Milfasartan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.