Description

L-161,982 is a selective and potent non-peptide antagonist of the angiotensin II type 2 (AT2) receptor. This compound is a critical research tool for elucidating the distinct physiological and pathological roles of the AT2 receptor, which is implicated in processes such as tissue repair, inflammation, and fibrosis. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) focused on cardiovascular, renal, and neurological disease models.

Application

• Pharmacological Research: A key reference standard for studying the AT2 receptor's signaling pathways and functions in vitro and in vivo.
• Cardiovascular Disease Models: Used to investigate the role of AT2 receptors in hypertension, heart failure, and vascular remodeling.
• Neurological Studies: Employed in research on stroke, cognitive function, and neuropathic pain where the AT2 receptor is a target.
• Renal Research: Applied in models of kidney fibrosis, diabetic nephropathy, and renal inflammation.
• Drug Discovery & Development: Serves as a lead compound or comparator in the development of novel AT2 receptor-targeted therapeutics.
• Biochemical Assay Development: Used as a standard in receptor binding and functional assays (e.g., calcium flux, cAMP) for high-throughput screening.

Basic Information

Product Name	L-161,982
CAS No.	147776-06-5
Molecular Formula	C24H28N4O4S
Molecular Weight	468.57 g/mol
Synonyms	L161982; 5,7-Diethyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-pyrazolo[1,5-b][1,2,4]triazole; PD-123319 (disputed isomer); AT2 Receptor Antagonist L-161,982; Angiotensin II AT2 Receptor Antagonist; BIBR 277 (related compound class)
EINECS	Contact for details

Quality Control

Our L-161,982 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for structural confirmation, and NMR for identity verification. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider under an inert atmosphere. Allow the product to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.