Description

Saprisartan CAS NO 146623-69-0 is a potent and selective angiotensin II receptor antagonist (ARB) used in pharmaceutical research and development. This compound is of significant interest for its role in studying cardiovascular therapeutics, particularly for the management of hypertension and related cardiac conditions. It is primarily utilized by pharmaceutical companies, academic research institutions, and contract research organizations (CROs) engaged in drug discovery and development.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel antihypertensive drugs.
• Cardiovascular Disease Studies: Used in preclinical and clinical research to investigate mechanisms of action, efficacy, and safety profiles for hypertension treatment.
• Biochemical Assays: Serves as a selective ligand in receptor binding studies and pharmacological screenings to understand angiotensin II receptor interactions.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Academic Research: Utilized in university and institutional labs for fundamental research on the renin-angiotensin system and its role in physiology and disease.
• Formulation Development: Aids in the development and stability testing of various dosage forms, such as tablets or capsules, containing ARB class drugs.

Basic Information

Product Name	Saprisartan
CAS No.	146623-69-0
Molecular Formula	C25H24N6O3
Molecular Weight	456.50 g/mol
Synonyms	Saprisartan; BIBR-363; BIBR 363; BIBR363; 2-Butyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[[4-(dimethylamino)-2-pyrimidinyl]oxy]methyl]-1H-imidazole; 2-Butyl-4-[[4-(dimethylamino)-2-pyrimidinyl]oxy]methyl]-5-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]imidazole
EINECS	Contact for details

Quality Control

Our Saprisartan is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F), in a dry environment. Keep the container sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.