Description

Zolasartan is a potent and selective angiotensin II receptor antagonist (ARB) used in pharmaceutical research and development. This compound is of significant interest for its potential therapeutic applications in managing cardiovascular conditions, particularly hypertension. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced angiotensin receptor blocker (ARB) drug candidates.
• Research & Development: Used in preclinical and clinical studies to investigate mechanisms of action and efficacy for cardiovascular diseases.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of sartan-class pharmaceuticals.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies on the renin-angiotensin system.

Basic Information

Product Name	Zolasartan
CAS No.	145781-32-4
Molecular Formula	C24H26N6O3
Molecular Weight	446.51 g/mol
Synonyms	Zolasartan; 2-Butyl-5-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-4-chloro-1H-imidazole-5-methanol; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol; BIBR 277; BIBR-277; DU-273; DU 273
EINECS	Contact for details

Quality Control

Our Zolasartan is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR) to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.