Description

Tasosartan CAS NO 145733-36-4 is a potent and selective angiotensin II receptor antagonist (ARB) used in pharmaceutical research and development. This compound is critical for investigating cardiovascular therapies, particularly for hypertension and heart failure. It is primarily utilized by pharmaceutical companies, academic research institutions, and contract research organizations (CROs) engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Cardiovascular Research: A key tool for studying the renin-angiotensin system (RAS), mechanisms of hypertension, and vascular biology.
• Drug Discovery & Development: Used in lead optimization, structure-activity relationship (SAR) studies, and as a precursor for novel ARB derivatives.
• Preclinical Studies: Employed in animal models to evaluate the efficacy, pharmacokinetics, and safety profiles of angiotensin II receptor blockade.
• Biochemical Assays: Acts as a specific ligand in receptor binding assays and enzymatic studies to screen for new therapeutic agents.

Basic Information

Product Name	Tasosartan
CAS No.	145733-36-4
Molecular Formula	C27H30N4O3
Molecular Weight	458.56 g/mol
Synonyms	Tasosartan; WAY-ANA 756; ANA-756; 2-Butyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[[2-(1H-tetrazol-5-yl)phenyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-Butyl-4-({2'-[2-(1H-tetrazol-5-yl)phenyl][1,1'-biphenyl]-4-yl}methyl)-2,4-dihydro-5H-1,2,4-triazol-3-one; 2-Butyl-5-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-4-[(2-(1H-tetrazol-5-yl)phenyl)methyl]-4H-1,2,4-triazol-3-one
EINECS	Contact for details

Quality Control

Our Tasosartan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.