Description

Forasartan is a potent and selective angiotensin II receptor antagonist (ARB) used in pharmaceutical research and development. This compound is of significant interest for its role in studying cardiovascular regulation and as a key intermediate or reference standard in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the discovery and development of antihypertensive and cardioprotective drugs.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and pharmacologically active compound in the discovery of new angiotensin receptor blockers.
• Cardiovascular Research: Used in preclinical studies to investigate mechanisms of blood pressure regulation, cardiac remodeling, and renal function.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key synthetic building block in the manufacturing process of finished drug products.
• Analytical Method Development: Employed as a high-purity standard for calibrating HPLC, LC-MS, and other analytical instruments in quality control laboratories.
• Metabolism and Pharmacokinetic Studies: Utilized to study the absorption, distribution, metabolism, and excretion (ADME) profiles of ARB-class drugs.

Basic Information

Product Name	Forasartan
CAS No.	145216-43-9
Molecular Formula	C27H28N6O3
Molecular Weight	484.55 g/mol
Synonyms	Forasartan; BIBR-363; DU-273; 2-Butyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4-[[4-(dimethylamino)-2-pyrimidinyl]methyl]-1H-imidazole-5-methanol; 2-Butyl-4-[[4-(dimethylamino)-2-pyrimidinyl]methyl]-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
EINECS	Contact for details

Quality Control

Our Forasartan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.