Description

Candesartan Cilexetil CAS NO 145040-37-5 is a potent and selective angiotensin II receptor blocker (ARB) prodrug, widely recognized as a key active pharmaceutical ingredient (API). This compound is critical for the formulation of antihypertensive medications, offering effective blood pressure control and cardiovascular protection. It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing and producing treatments for hypertension and heart failure.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension.
• Cardiovascular Drug Formulations: Used in the development and production of tablets, capsules, and combination therapies targeting angiotensin II receptors.
• Generic Drug Manufacturing: A critical component for companies producing generic versions of branded antihypertensive medications containing candesartan.
• Clinical Research: Serves as a reference standard and raw material in pharmacokinetic, pharmacodynamic, and bioavailability studies.
• Drug Discovery & Development: Used in preclinical research for investigating new ARB-based therapies or combination treatments.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of pharmaceutical products under cGMP.

Basic Information

Product Name	Candesartan Cilexetil
CAS No.	145040-37-5
Molecular Formula	C33H34N6O6
Molecular Weight	610.66 g/mol
Synonyms	Candesartan Cilexetil; (±)-1-Hydroxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate; TCV-116; Atacand; Blopress; Kenzen; Amias; (2-Ethoxy-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazol-7-yl)methyl 1-hydroxyethyl carbonate; Candesartan Cilexetil API
EINECS	Contact for details

Quality Control

Our Candesartan Cilexetil is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical applications. Quality is assured through comprehensive analytical testing, including HPLC for assay and impurity profiling. We provide full traceability and support regulatory submissions with Certificates of Analysis (COA) and relevant documentation. The material is typically produced to meet or exceed specifications outlined in major pharmacopoeias such as USP and EP.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.