Description

Pomisartan CAS NO 144702-17-0 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. It serves as a key building block in the synthesis of advanced therapeutic agents, particularly within the cardiovascular and metabolic disease treatment segments. This compound is essential for manufacturers and research institutions engaged in the development and production of novel angiotensin II receptor blockers (ARBs) and related pharmaceuticals. Its consistent quality and reliable supply are critical for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the multi-step synthesis of potent angiotensin II receptor antagonist drugs.
• Active Pharmaceutical Ingredient (API) R&D: Serves as a core structural component in research and development for new cardiovascular and antihypertensive medications.
• Reference Standard: Used in analytical laboratories as a high-purity standard for quality control, method development, and validation in pharmaceutical manufacturing.
• Biochemical Research: Employed in pharmacological studies to investigate mechanisms of action related to the renin-angiotensin system.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial drug batches.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for cost-effective and robust API production.

Basic Information

Product Name	Pomisartan
CAS No.	144702-17-0
Molecular Formula	C24H20N6O3
Molecular Weight	440.45 g/mol
Synonyms	Pomisartan; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid; BIBR-277; BIBR 277; BIBR277; 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-; Telmisartan Impurity; Telmisartan Related Compound A
EINECS	Contact for details

Quality Control

Every batch of Pomisartan is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the highest purity standards for pharmaceutical applications. Our quality control protocols are designed to guarantee batch-to-batch consistency, identity, purity, and strength. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific pharmacopeial requirements (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.