Description

Ethyl -2-Ethoxy-1-[[(2-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl] is a high-purity, non-peptide biphenyl tetrazole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a key structural motif for investigating novel therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of new active pharmaceutical ingredients (APIs). The material is supplied with a focus on consistent quality and reliable supply to support critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of sartan-class active pharmaceutical ingredients (APIs) and other novel drug candidates targeting cardiovascular and metabolic diseases.
• Angiotensin II Receptor Antagonist Research: Serves as a core structural component for developing and testing new non-peptide AT1 receptor blockers.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of tetrazole-containing drug molecules.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of advanced pharmaceutical intermediates.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.
• Biochemical Research: Applied in biochemical assays to study receptor-ligand interactions and enzyme inhibition mechanisms.

Basic Information

Item	Detail
Product Name	Ethyl -2-Ethoxy-1-[[(2-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]
CAS No.	139481-58-6
Molecular Formula	C24H23N5O2
Molecular Weight	413.47 g/mol
Synonyms	Ethyl 2-Ethoxy-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylate; 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, ethyl ester; BIBR 277; BIBR-277; Telmisartan Impurity; Telmisartan Intermediate; Biphenyltetrazole Derivative
EINECS	Contact for details

Quality Control

Our Ethyl -2-Ethoxy-1-[[(2-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl] is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.