Description

Abitesartan CAS NO 137882-98-5 is a high-purity, non-peptide angiotensin II receptor antagonist (ARB) used in pharmaceutical research and development. This compound is critical for investigating cardiovascular therapies, particularly for hypertension and heart failure, by selectively blocking the AT1 receptor. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular drugs.
• Biochemical Research: Used as a reference standard and tool compound in studies of the renin-angiotensin system (RAS) and its role in blood pressure regulation.
• Drug Discovery & Development: A vital candidate for screening and developing new generations of sartan-class antihypertensive medications.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate pharmacokinetics, pharmacodynamics, and therapeutic efficacy.
• Analytical Standard: Provides a high-purity benchmark for quality control and method validation in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	Abitesartan
CAS No.	137882-98-5
Molecular Formula	C27H28N6O3
Molecular Weight	484.55 g/mol
Synonyms	Abitesartan; BMS-248360; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic Acid; BMS 248360; BMS248360
EINECS	Contact for details

Quality Control

Our Abitesartan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.