Description

Valsartan CAS NO 137863-60-6 is a potent and selective angiotensin II receptor antagonist (ARB) belonging to the sartan class of active pharmaceutical ingredients (APIs). This compound is critical for the formulation of antihypertensive and cardiovascular medications, effectively managing high blood pressure and heart failure. It is an essential raw material for global pharmaceutical manufacturers engaged in the production of finished dosage forms, including tablets and capsules, for both branded and generic drug markets.

Application

• Primary Pharmaceutical Ingredient: Core active component in antihypertensive medications for the treatment of hypertension.
• Cardiovascular Therapeutics: Used in drug formulations for heart failure management and post-myocardial infarction care.
• Generic Drug Manufacturing: A key API for the production of cost-effective generic versions of branded valsartan medications.
• Fixed-Dose Combination Drugs: Combined with other antihypertensive agents like hydrochlorothiazide or amlodipine in single-pill formulations.
• Pharmaceutical Research & Development: Serves as a reference standard and starting material in cardiovascular drug discovery and analytical method development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for commercial-scale tablet and capsule production.

Basic Information

Product Name	Valsartan
CAS No.	137863-60-6
Molecular Formula	C24H29N5O3
Molecular Weight	435.52 g/mol
Synonyms	Valsartan; N-Valeryl-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; CGP 48933; Tareg; Diovan (brand name); N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; (S)-N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]valine
EINECS	Contact for details

Quality Control

Our Valsartan API is manufactured under strict quality management systems, ensuring it meets the stringent requirements of global pharmacopoeias. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, to guarantee compliance with USP, EP, and ICH Q3A/B guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes such as assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.15%; Total impurities: ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Microbial Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.