Description

Isoleucine Valsartan CAS NO 137862-78-3 is a high-purity, non-peptide angiotensin II receptor antagonist (ARB) specifically designed for advanced pharmaceutical research and development. This compound is a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel sartan-class antihypertensive medications. It is essential for pharmaceutical manufacturers and R&D laboratories focused on developing next-generation cardiovascular therapies, including combination drugs and prodrugs with improved efficacy and patient compliance profiles.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of finished dosage forms for hypertension and heart failure treatment.
• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of novel valsartan analogs and derivatives.
• Research & Development: Used in preclinical and clinical studies to investigate new mechanisms of action and therapeutic combinations for cardiovascular diseases.
• Reference Standard: Serves as a high-purity chemical standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Combination Drug Development: A key component in the development of fixed-dose combination therapies, often paired with other antihypertensive agents like diuretics or calcium channel blockers.
• Prodrug Synthesis: Utilized as a precursor for creating prodrug versions of valsartan aimed at enhancing bioavailability or specific tissue targeting.

Basic Information

Product Name	Isoleucine Valsartan
CAS No.	137862-78-3
Molecular Formula	C24H29N5O3
Molecular Weight	435.52 g/mol
Synonyms	Valsartan Isoleucine; (S)-N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, (S)-; N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; ILE-VAL; Valsartan Ile Ester
EINECS	Contact for details

Quality Control

Our Isoleucine Valsartan is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and stringent control of residual solvents and impurities in accordance with ICH guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with pharmaceutical-grade requirements for R&D and API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.