Description

Valsartan CAS NO 137862-53-4 is a potent and selective angiotensin II receptor antagonist (ARB) used as an active pharmaceutical ingredient (API). It is a critical compound in the global pharmaceutical supply chain for the treatment of hypertension and heart failure. This high-purity intermediate is essential for manufacturers of finished dosage forms, including tablets and capsules, targeting cardiovascular diseases.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and heart failure medications.
• Finished Dosage Formulation: Direct compression into tablets or filling into capsules for oral administration.
• Combination Drug Products: Used in fixed-dose combination therapies with other antihypertensives like hydrochlorothiazide or amlodipine.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded ARB drugs.
• Clinical Trial Material: Supply of GMP-grade material for pharmaceutical research and development studies.
• Reference Standard: High-purity material for analytical testing and quality control laboratories.

Basic Information

Product Name	Valsartan
CAS No.	137862-53-4
Molecular Formula	C24H29N5O3
Molecular Weight	435.52 g/mol
Synonyms	N-Valeryl-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; (S)-N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; CGP 48933; Tareg; Diovan (brand name); N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-L-valine
EINECS	Contact for details

Quality Control

Our Valsartan is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopoeial standards such as USP, EP, and JP. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	-64.0° to -69.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.