Description

4(3H)-Quinazolinone, 2-Butyl-6,7,8-Trimethoxy-3-[[2-(1H-Tetrazol-5-Yl)[1,1-Biphenyl]-4-Yl]Methyl]- (9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of cardiovascular and antihypertensive therapeutics. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sartan-class antihypertensive drugs, specifically angiotensin II receptor blockers (ARBs).
• Research & Development: Serves as a key scaffold for medicinal chemists exploring new quinazolinone and tetrazole-based bioactive molecules.
• Process Chemistry: Used in the optimization and scale-up of API manufacturing routes under cGMP conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Reference Standard: High-purity grades are suitable for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	4(3H)-Quinazolinone, 2-Butyl-6,7,8-Trimethoxy-3-[[2-(1H-Tetrazol-5-Yl)[1,1-Biphenyl]-4-Yl]Methyl]- (9Ci)
CAS No.	137416-81-0
Molecular Formula	C29H30N6O4
Molecular Weight	526.59 g/mol
Synonyms	2-Butyl-6,7,8-trimethoxy-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-4(3H)-quinazolinone; BIBR 277; BIBR-277; BIBR277; Valsartan Impurity; Valsartan Related Compound; Telmisartan Intermediate; Tetrazole Quinazolinone Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR, MS). We ensure compliance with relevant ICH guidelines for impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.