Description

2-Butyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]Benzoimidazole -4-Carboxylic Acid is a high-purity, non-peptide angiotensin II receptor antagonist intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting cardiovascular conditions. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of sartan-class antihypertensive drugs.

Application

• Key Intermediate for Sartan APIs: Serves as a core precursor in the synthesis of advanced angiotensin II receptor blockers (ARBs) such as Valsartan and related compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new non-peptide receptor antagonists.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial API manufacturing.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.
• Fine Chemical Synthesis: Utilized for the custom synthesis of complex, tetrazole-containing molecules for specialized research applications.

Basic Information

Product Name	2-Butyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]Benzoimidazole -4-Carboxylic Acid
CAS No.	136284-47-4
Molecular Formula	C26H24N6O2
Molecular Weight	452.51 g/mol
Synonyms	Valsartan Intermediate; 2-Butyl-3-{[4-(2-2H-tetrazol-5-ylphenyl)phenyl]methyl}-1H-benzimidazole-4-carboxylic acid; 2-Butyl-3-[[4'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-2-yl]methyl]-1H-benzimidazole-4-carboxylic Acid; L-Valine, N-(1-oxopentyl)-, N-[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-N-valeryl-; (S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine Cyclization Product; Valsartan Key Intermediate; Benzimidazole-tetrazole biphenyl derivative.
EINECS	Contact for details

Quality Control

Our 2-Butyl-3-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]Benzoimidazole -4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.