Description

Fasidotril is a dual-acting vasopeptidase inhibitor, representing a significant class of compounds in cardiovascular research. Its primary value lies in its ability to simultaneously inhibit both angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP), offering a unique mechanism for modulating blood pressure and cardiovascular function. This high-purity intermediate is essential for pharmaceutical R&D teams and manufacturers developing next-generation therapeutic agents for hypertension and heart failure.

Application

• Pharmaceutical Intermediate: Critical raw material for the synthesis of advanced cardiovascular drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in studies of the renin-angiotensin-aldosterone system (RAAS) and natriuretic peptide system.
• Mechanism of Action Studies: Employed in preclinical research to investigate the dual inhibition of ACE and NEP enzymes.
• Process Development: Serves as a key building block in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Analytical Standard: Used for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.

Basic Information

Product Name	Fasidotril
CAS No.	135038-57-2
Molecular Formula	C20H28N2O5S
Molecular Weight	408.51 g/mol
Synonyms	Fasidotril; (2R,4R)-4-[[(2S)-3-Mercapto-2-methyl-1-oxopropyl]amino]-5-oxo-2-[[(phenylmethoxy)carbonyl]amino]-N,1-pentanedihydroxamic acid; BMS-186716; S 21402; Dual NEP/ACE inhibitor; Vasopeptidase inhibitor; N-(2-Carboxy-1-oxo-3-phenylpropyl)-L-alanyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our Fasidotril is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. We provide comprehensive analytical data to support your regulatory and process requirements. A detailed Certificate of Analysis (COA), including purity by HPLC, identification (IR, NMR), and impurity profile, is supplied with each batch and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.