Description

R-(-)-Manidipine is the pharmacologically active enantiomer of the calcium channel blocker manidipine. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure antihypertensive and cardiovascular active pharmaceutical ingredients (APIs). It is essential for pharmaceutical R&D and production facilities focused on creating stereoselective drugs with optimized efficacy and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of the antihypertensive drug manidipine and its derivatives.
• Cardiovascular Drug Research: Enantioselective research and development of novel dihydropyridine-class calcium channel blockers.
• API Manufacturing: Production of high-purity, single-enantiomer Active Pharmaceutical Ingredients (APIs) for final dosage forms.
• Reference Standard: Serves as an analytical standard for quality control, method development, and regulatory submissions.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway studies for drug development programs.

Basic Information

Product Name	R-(-)-Manidipine
CAS No.	133082-19-6
Molecular Formula	C35H38N4O6
Molecular Weight	610.70 g/mol
Synonyms	(R)-Manidipine; (-)-Manidipine; R-Manidipine; (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester; Manidipine R enantiomer; CAS 133082-19-6; (R)-(-)-Manidipine
EINECS	Contact for details

Quality Control

Our R-(-)-Manidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.