Description

Lercanidipine Hydrochloride is a high-purity active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical component in the formulation of antihypertensive medications, valued for its vasodilatory effects and improved tolerability profile. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for cardiovascular diseases, including hypertension and angina.

Application

• Pharmaceutical API: Primary active ingredient in antihypertensive drug formulations.
• Hypertension Treatment: Used in the manufacture of tablets and capsules for managing high blood pressure.
• Cardiovascular Research: Reference standard and key intermediate in pharmacological and clinical studies.
• Generic Drug Production: Sourcing for the development and production of generic versions of branded calcium channel blockers.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and HPLC/LC-MS analysis.
• Preclinical Development: Utilized in pharmacokinetic, metabolic, and toxicology studies during drug discovery.

Basic Information

Product Name	Lercanidipine Hydrochloride
CAS No.	132866-11-6
Molecular Formula	C36H41N3O6 • HCl
Molecular Weight	648.19 g/mol
Synonyms	Lercanidipine HCl; (2S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride; Masnidipine Hydrochloride; Lercadip; Zanidip; Lercanidipinum hydrochloridum; Lercanidipine Hydrochloride (USP)
EINECS	Contact for details

Quality Control

Our Lercanidipine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with typical purity levels exceeding 99.0%. Certificates of Analysis (COA) are available upon request, detailing comprehensive testing including assay, related substances, residual solvents, and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Unknown Impurity	≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.