Description

Cilnidipine is a potent, long-acting dihydropyridine calcium channel blocker used primarily as an antihypertensive agent. Its dual action on both L-type and N-type calcium channels offers a distinct therapeutic profile, potentially reducing side effects like tachycardia associated with other medications in its class. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing and producing advanced cardiovascular medications. It is supplied as Cilnidipine CAS NO 132203-70-4 to meet the stringent requirements of global regulatory submissions and commercial drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive tablet formulations.
• Cardiovascular Drug Development: Key intermediate in research and development of new calcium channel blockers.
• Fixed-Dose Combination Drugs: Used in combination with other antihypertensive agents like angiotensin II receptor blockers (ARBs).
• Clinical Trial Material: Sourced for Phase I-IV clinical studies requiring GMP-grade material.
• Reference Standard: Serves as a high-purity chemical standard for analytical method development and quality control laboratories.
• Generic Drug Manufacturing: Critical for companies producing bioequivalent versions of branded cilnidipine medications.

Basic Information

Product Name	Cilnidipine
CAS No.	132203-70-4
Molecular Formula	C27H28N2O7
Molecular Weight	492.52 g/mol
Synonyms	FRC-8653; Cinalong; Siscard; Atelec; Cilacar; (±)-Cilnidipine; 3-O-1-benzyl-3-pyrrolidinyl 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-benzyl-3-pyrrolidinyl) ester 5-methyl ester
EINECS	Contact for details

Quality Control

Our Cilnidipine is manufactured under strict quality management systems to ensure it meets the highest standards for pharmaceutical use. Each batch is tested against comprehensive specifications, including identity, purity, and impurity profiles, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support regulatory filings and can supply material manufactured under current Good Manufacturing Practice (GMP) conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants in the container.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.