Description

Isradipine is a potent and selective dihydropyridine calcium channel blocker used primarily in pharmaceutical research and development. Its mechanism of action makes it a critical compound for studying cardiovascular physiology and developing new therapeutic agents. This high-purity material is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on hypertension and related cardiovascular disorders. Isradipine CAS NO 131970-21-3 is supplied under stringent quality controls to ensure reliability and consistency for sensitive applications.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Primary use as the active component in the formulation of antihypertensive and antianginal medications.
• Biomedical Research: A key tool compound for in vitro and in vivo studies investigating calcium channel function, vascular smooth muscle contraction, and cardiac electrophysiology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical testing laboratories.
• Preclinical Development: Used in pharmacokinetic, pharmacodynamic, and toxicology studies during the drug discovery and development pipeline.
• Formulation Development: Employed in the development of various dosage forms, including tablets and controlled-release formulations.

Basic Information

Product Name	Isradipine
CAS No.	131970-21-3
Molecular Formula	C19H21N3O5
Molecular Weight	371.39 g/mol
Synonyms	PN 200-110; Isrodipine; Lomir; Prescal; (4RS)-4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-benzoxazolyl)-, methyl 1-methylethyl ester
EINECS	Contact for details

Quality Control

Our Isradipine is manufactured and tested to meet the exacting standards required for pharmaceutical research and development. Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques such as HPLC, IR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for each lot, detailing all test results against established specifications. Our quality system is designed to support compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.